Schedules of Controlled Substances - Drug Manufacturers and Distributors

Amendments and Updates

• Order Temporarily Placing N-Desethyl Isotonitazene and N-Piperidinyl Etonitazene in Schedule I
  Effective April 4, 2025
  Published in the March 14, 2025, edition of the Texas Register (50 TexReg 1982)

• Order Placing Ethylphenidate in Schedule I
  Effective April 4, 2025
  Published in the March 14, 2025, edition of the Texas Register (50 TexReg 1982)

• Order Placing Butonitazene, Flunitazene, and Metodesnitazene in Schedule I
  Effective April 4, 2025
  Published in the March 14, 2025, edition of the Texas Register (50 TexReg 1982)

• Order Placing 2-Methyl AP-237 into Schedule I
  Effective November 08, 2024
  Published in the October 18, 2024, edition of the Texas Register (49 TexReg 8490)

• Order Placing Etodesnitazene, NPyrrolidino Etonitazene, and Protonitazene into Schedule I 
  Effective November 08, 2024
  Published in the October 18, 2024, edition of the Texas Register (49 TexReg 8490)

• Order Extending the Temporary Placement of Butonitazene, Flunitazene, and Metodesnitazene in Schedule I
  Effective November 08, 2024
  Published in the October 18, 2024, edition of the Texas Register (49 TexReg 8491)

2024 Schedules of Controlled Substances

2024 Republication of Schedules

• Order Placing Zuranolone into Schedule IV
  Effective April 19, 2024
  Published in the March 29, 2024, edition of the Texas Register (49 TexReg 2113)

• Order Placing Nine Specific Fentanyl-Related Substances into Schedule I
  Effective April 19, 2024
  Published in the March 29, 2024, edition of the Texas Register (49 TexReg 2113)

• Order Temporarily Placing MDMB-4en-PINACA, 4F-MDMBBUTICA, ADB-4en-PINACA, CUMYL-PEGACLONE, 5F-EDMB-PICA, and MMB-FUBICA into Schedule I
  Effective April 19, 2024
  Published in the March 29, 2024, edition of the Texas Register (49 TexReg 2114)

• Order Temporarily Placing Etizolam, Flualprazolam, Clonazolam, Flubromazolam, and Diclazepam into Schedule I
  Effective March 1, 2023
  Published in the February 9, 2024, edition of the Texas Register (49 TexReg 770)

• Order Implementing the Designer Steroid Control Act of 2014
  Effective March 1, 2023
  Published in the February 9, 2024, edition of the Texas Register (49 TexReg 770)

• Order Permanently Placing Metonitazene into Schedule I
  Effective March 1, 2023
  Published in the February 9, 2024, edition of the Texas Register (49 TexReg 771)

• Order Placing Brorphine in Schedule I
  Effective July 28, 2023
  Published in the July 7, 2023, edition of the Texas Register (48 TexReg 3731)

• Order Placing Eutylone in Schedule I
  Effective July 28, 2023
  Published in the July 7, 2023, edition of the Texas Register (48 TexReg 3731)

• Order Adding Ganaxolone to Schedule V
  Effective May 19, 2023
  Published in the April 28, 2023 edition of the Texas Register (48 TexReg 2213)

• Order Adding Amineptine to Schedule I
  Effective May 19, 2023
  Published in the April 28, 2023 edition of the Texas Register (48 TexReg 2213)

• Order Adding Methiopropamine to Schedule I 
  Effective May 19, 2023 
  Published in the April 28, 2023 edition of the Texas Register (48 TexReg 2214)

• Order Adding Mesocarb to Schedule I
  Effective May 19, 2023
  Published in the April 28, 2023 edition of the Texas Register (48 TexReg 2214)

• Order Adding Zipeprol to Schedule I
  Effective May 19, 2023
  Published in the April 28, 2023 edition of the Texas Register (48 TexReg 2214)

• Order Removing Fenfluramine from Schedule IV 
  Effective May 19, 2023 
  Published in the April 28, 2023 edition of the Texas Register (48 TexReg 2215)

2023 Schedules of Controlled Substances

2023 Schedules of Controlled Substances

• Order placing Methoxetamine into Schedule I
  Effective November 4, 2022
  Published in the October 14, 2022 edition of the Texas Register (47 TexReg 6903)   

• Order maintaining Serdexmethylphenidate in Schedule IV
  Effective November 4, 2022
  Published in the October 14, 2022 edition of the Texas Register (47 TexReg 6903)

• Order placing Ganaxolone into Schedule V 
  Effective October 21, 2022
  Published in the September 30, 2022 edition of the Texas Register (47 TexReg 6494)

• Order placing N-ethylhexedrone, α-PHP, 4–MEAP, MPHP, PV8, and 4-chloro-α-PVP into Schedule I
  Effective October 21, 2022
  Published in the September 30, 2022 edition of the Texas Register (47 TexReg 6494)

• Order placing Daridorexant into Schedule IV
  Effective August 26, 2022
  Published in the August 5, 2022 edition of the Texas Register (47 TexReg 4739)
   
• Order permanently placing 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, andFUB-144 in schedule I
  Effective August 26, 2022
  Published in the August 5, 2022 edition of the Texas Register (47 Tex Reg 4739)  

• Order Placing 4,4′-DMAR and Isotonitazine into Schedule I
  Effective July 17, 2022
  Published in the June 24, 2022 edition of the Texas Register (47 TexReg 2730)

• Correction of Error
  Effective June 24, 2022
  Published in the June 3, 2022 edition of the Texas Register (47 TexReg 3320)

2022 Schedules of Controlled Substances

2022 Schedules of Controlled Substances

• Notice of Compliance with Temporary Injunction Issued by Presiding Judge Jan Soifer on November 8, 2021 Ordering DSHS to Change the Definitions of Tetrahydrocannabinol and Marihuana Extract
  Effective February 11, 2022
  Published in the January 1, 2022 edition of the Texas Register (47 TexReg 175)

• Order Placing PMMA in Schedule I
  Effective February 11, 2022
  Published in the January 1, 2022 edition of the Texas Register (47 TexReg 175)

• Order Extending the Temporary Scheduling of Six Cathinones
  Effective February 11, 2022
  Published in the January 1, 2022 edition of the Texas Register (47 TexReg 175)

• Order Maintaining Remimazolam in Schedule IV
  Effective February 11, 2022
  Published in the January 1, 2022 edition of the Texas Register (47 TexReg 175)
   
• Order permanently placing NM2201, 5F-AB-PINACA, 4-CN-CUMYL-BUTINACA, MMB-CHMICA, 5F-CUMYL-P7AICA into schedule I
  Effective October 29, 2021.
  Published in the October 8, 2021 edition of the Texas Register (46 TexReg 6990).

• Order permanently placing N-ethylpentylone into schedule I
  Effective October 29, 2021.
  Published in the October 8, 2021 edition of the Texas Register (46 TexReg 6990).

• Order creating a separate listing for 4F-MDMB-BUTINACA in schedule I
  Effective October 29, 2021.
  Published in the October 8, 2021 edition of the Texas Register (46 TexReg 6990).

• Order maintaining lasmiditan in schedule V
  Effective October 29, 2021.
  Published in the October 8, 2021 edition of the Texas Register (46 TexReg 6990).

• Order adding the substances β-methyl fentanyl, β’-phenyl fentanyl, 2'-fluoro o-fluorofentanyl, 4'-methyl acetyl fentanyl, o-fluorobutyryl fentanyl, o-methyl acetylfentanyl, o-methyl methoxyacetyl fentanyl, p-methylfentanyl, phenyl fentanyl, thiofuranyl fentanyl to schedule I
  Effective  August 13, 2021.
  Published in the July 23, 2021 edition of the Texas Register (46 TexReg 4479).

• Order adding the substances fentanyl carbamate, o-fluoroacryl, o-fluoroisobutyryl fentanyl, and p-fluoro furanyl fentanyl to schedule I
  Effective  August 13, 2021.
  Published in the July 23, 2021 edition of the Texas Register (46 TexReg 4479).

• Order extending the temporary scheduling of the substances 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA and FUB-144
  Effective  August 13, 2021.
  Published in the July 23, 2021 edition of the Texas Register (46 TexReg 4479).

• Order removing samidorphan from schedule II
  Effective  August 13, 2021.
  Published in the July 23, 2021 edition of the Texas Register (46 TexReg 4479).

• Order adding serdexmethylphenidate to schedule IV
  Effective  August 13, 2021.
  Published in the July 23, 2021 edition of the Texas Register (46 TexReg 4479).

• Amendment placing cyclopentyl fentanyl, isobutyryl fentanyl, para-chloroisobutyryl, para-methoxybutyryl fentanyl and valeryl fentanyl into schedule I
  Effective July 16, 2021
  Published in the June 25, 2021 edition of the Texas Register (46 TexReg 3956) 

• Order temporarily placing brorphine into schedule I
  Effective July 16, 2021
  Published in the June 25, 2021 edition of the Texas Register (46 TexReg 3956)
   
• Order permanently placing lemborexant into Schedule IV
  Effective July 16, 2021
  Published in the June 25, 2021 edition of the Texas Register (46 TexReg 3956)

2021 Schedules of Controlled Substances

2021 Schedules of Controlled Substances

• Decision Order Regarding the Modification of the Definition of Tetrahydrocannabinols in Schedule I of the Schedules of Controlled Substances
  Effective February 19, 2021
  Published in the January 29, 2021 edition of the Texas Register (46 TexReg 873)

• Amendment Placing Oliceridine in Schedule II
  Effective January 29, 2021
  Published in the January 8, 2021 edition of the Texas Register (46 TexReg 348)  

• Amendment Adding Remimazolam to Schedule IV and Maintaining Crotonyl Fentanyl in Schedule I
  Effective January 8, 2021
  Published in the December 18, 2020 edition of the Texas Register ( 45 TexReg 9313)

• Order extending the temporary scheduling of n-Ethylpentalone in schedule I
  Effective January 1, 2021
  Published in the December 11, 2020 edition of the Texas Register (45 TexReg 8914)

• Order removing cannabidiol drugs from schedule V
  Effective November 13, 2020
  Published in the October 23, 2020 edition of the Texas Register (45 TexReg 7643)

• Order adding cenobamate to schedule V
  Effective November 13, 2020
  Published in the October 23, 2020 edition of the Texas Register (45 TexReg 7643)

• Order temporarily adding isotonitazene to schedule I
  Effective November 13, 2020
  Published in the October 23, 2020 edition of the Texas Register (45 TexReg 7643)

• Order extending the temporary scheduling of NM2201, 5F-AB-PINACA, 4-CN-CUMYL-BUTINACA, MMB-CHMICA, and 5F-CUMYL-P7AICA in Schedule I
  Effective October 23, 2020
  Published in the October 2, 2020 edition of the Texas Register (45 TexReg 7067)

• Order adding FUB-AMB to schedule I
  Effective September 18, 2020
  Published in the August 28, 2020 edition of the Texas Register (45 TexReg 6152)

• Order adding lemborexant to schedule IV
  Effective September 18, 2020
  Published in the August 28, 2020 edition of the Texas Register (45 TexReg 6152)

• Order extending the temporary placement of valeryl fentanyl, para-methoxybutyryl fentanyl, para-chloroisobutyryl fentanyl, isobutyryl fentanyl, and cyclopentyl fentanyl in schedule I.
  Effective Jun 26, 2020.
  Published in the June 5, 2020 edition of the Texas Register (45 TexReg 3905)
   
• Order maintaining the placement of solriamfetol in schedule IV.
  Effective Jun 26, 2020.
  Published in the June 5, 2020 edition of the Texas Register (45 TexReg 3905)
   
• Order placing 5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA and MDMB-FUBINACA into schedule I.
  Effective Jun 26, 2020.
  Published in the June 5, 2020 edition of the Texas Register (45 TexReg 3905)
   
• Order removing 6-beta-naltrexol from schedule II.
  Effective Jun 26, 2020.
  Published in the June 5, 2020 edition of the Texas Register (45 TexReg 3905)
   
• Order maintaining brexanolone in schedule IV.
  Effective Jun 26, 2020.
  Published in the June 5, 2020 edition of the Texas Register (45 TexReg 3905)
   
• Order placing lasmiditan into schedule V.
  Effective Jun 26, 2020.
  Published in the June 5, 2020 edition of the Texas Register (45 TexReg 3905)
   
• Order placing cenobamate into schedule V.
  Effective Jun 26, 2020
  Published in the June 5, 2020 edition of the Texas Register (45 TexReg 3905)

2020 Schedules of Controlled Substances

2020 Schedules of Controlled Substances

• Order placing cyclopropyl fentanyl, methoxyacetyl fentanyl, ortho-fluorofentanyl and para-fluorobutyryl fentanyl into schedule
  Effective February 28, 2020
  Published in the February 7, 2020 edition of the Texas Register (45 TexReg 949)
   
• Order extending temporary schedule I status of FUB-AMB
  Effective February 14, 2020
  Published in the January 24, 2020 edition of the Texas Register (45 TexReg 644)
   
• Amendment adding a separate listing for noroxymorphone in schedule II
  Effective October 18, 2019
  Published in the September 27, 2019 edition of the Texas Register (44 TexReg 5661)
   
• Order Temporarily Placing N-Ethylhexedrone, αlpha-PHP, 4–MEAP, MPHP, PV8, and 4-Chloro-alpha-PVP into Schedule I
  Effective October 4, 2019
  The order was published in the September 11, 2019 issue of the Texas Register (44 TexReg 5183)
   
• Order placing brexanolone into Schedule IV
  Effective September 20, 2019
  The order was published in the August 30, 2019 issue of the Texas Register (44 TexReg 4769)
   
• Order placing solriamfetol into schedule IV
  Effective September 20, 2019
  The order was published in the August 30, 2019 issue of the Texas Register (44 TexReg 4769)
   
• Order permanently placing thiafentanil into schedule II
  Effective September 20, 2019
  The order was published in the August 30, 2019 issue of the Texas Register (44 TexReg 4769)
   
• Order permanently placing beta-hydroxythiofentanyl in schedule I
  Effective August 2, 2019
  The order was published in the July 12, 2019 issue of the Texas Register (44 TexReg 3570)
   
• Order adding the chemical names of five substances that fall within the definition of fentanyl-related substances
  Effective July 11, 2019
  The amendment was published in the June 21, 2019 issue of the Texas Register (44 TexReg 3173)
   
• Order temporarily placing the synthetic cannabinoids 5FEDMB-PINACA; 5F-MDMB-PICA; FUB-APINACA; 5F-CUMYL-PINACA; and FUB-144 into schedule I
  Effective July 11, 2019
  The amendment was published in the June 21, 2019 issue of the Texas Register (44 TexReg 3173)
   
• Order extending the temporary schedule I status of 5F–MDMB–PINACA; 5F–AMB; 5F–APINACA; ADB–FUBINACA; MDMB–CHMICA, MMB–CHMINACA; and MDMB–FUBINACA
  Effective July 11, 2019
  The amendment was published in the June 21, 2019 issue of the Texas Register (44 TexReg 3173)2019 Schedules of Controlled Substances

2019 Schedules of Controlled Substances

2019 Schedules of Controlled Substances

Effective June 7, 2019
The republication was published in the May 17, 2019 issue of the Texas Register (44 TexReg 2514)

• Amendment maintaining butyryl fentanyl and U-47700 in Schedule I 
  Effective June 7, 2019
  The amendment was published in the May 17 2019 issue of the Texas Register (44 TexReg 2514)
   
• Amendment placing furanyl fentanyl, 4-fluoroisobutyryl fentanyl, acryl fentanyl, tetrahydrofuranyl fentanyl, and ocfentanil into Schedule I 
  Effective June 7, 2019
  The amendment was published in the May 17 2019 issue of the Texas Register (44 TexReg 2514) 
   
• Amendment placing MAB-CHMINACA into Schedule I 
  Effective June 7, 2019
  The amendment was published in the May 17 2019 issue of the Texas Register (44 TexReg 2514)
   
• Amendment removing hemp, as defined by the Agricultural Marketing Act of 1946, from Schedule I
  Effective April 5, 2019
  The amendment was published in the March 15, 2019 issue of the Texas Register.
   
• Amendment temporarily placing N-ethylpentylone into schedule I  
  Effective November 23, 2018.
  The amendment was published in the November 2, 2018 issue of the Texas Register. 
   
• Amendment adding drug products in finished dosage formulation that has been approved by the U.S. Food and Drug Administration that contains cannabidiol (2-[1R-3-methyl-6R-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol) derived from cannabis and no more than 0.1 percent (w/w) residual tetrahydrocannabinols to Schedule V 
  Effective November 9, 2018The amendment was published in the November 9, 2018 issue of the Texas Register.
   
• Amendment temporarily placing the substances NM2201, 5F-AB-PINACA, 4-CN-CUMYL-BUTINACA, MMB-CHMICA, and 5F-CUMYL-P7AICA into schedule I 
  Effective September 19, 2018.
  The amendment was published in the August 31, 2018 issue of the Texas Register.
   
• Amendment temporarily adding cyclopropyl fentanyl to schedule I 
  Effective May 25, 2018
  The amendment was published in the May 4, 2018 issue of the Texas Register.
   
• Amendment placing MT-45 into schedule I
  Effective May 25, 2018
  The amendment was published in the May 4, 2018 issue of the Texas Register.
   
• Amendment temporarily adding valeryl fentanyl, para-fluorobutyryl fentanyl, para-methoxybutyryl fentanyl, para-chloroisobutyryl; isobutyryl fentanyl; cyclopentyl fentanyl; and ocfentanil into schedule I
  Effective May 25, 2018
  The amendment was published in the May 4, 2018 issue of the Texas Register.
   
• Amendment temporarily adding fentanyl-related substances not currently listed in any schedule into schedule I
  Effective May 25, 2018
  The amendment was published in the May 4, 2018 issue of the Texas Register.

2018 Schedules of Controlled Substances

• 2018 Schedules of Controlled Substances
  Effective February 23, 2018
  The republication was published in the February 2, 2018 issue of the Texas Register (43 TexReg 606) 

• Amendment temporarily adding ortho-fluorofentanyl, tetrahydrofuranyl fentanyl, and methoxyacetyl fentanyl to schedule I

          Effective January 5, 2018 

          The amendment was published in the December 15, 2017 issue of the Texas Register.

• Amendment temporarily adding FUB-AMB to schedule I
  Effective January 5, 2018 
  This amendment was published in the December 15, 2017 issue of the Texas Register.

2017 Schedules of Controlled Substances

• 2017 Schedules of Controlled Substances 

          Effective April 7, 2017

          The republication was published in the March 17, 2017 issue of the Texas Register (42              TexReg 1271)

Recent Changes to Schedules of Controlled Substances

• Amendment removing naldemedine from schedule II
  Effective December 29, 2017
  The amendment was published in the December 8, 2017 issue of the Texas Register. 
   
• Amendment moving acetyl fentanyl from temporary to final schedule I
  Effective October 20, 2017
  The amendment was published in the September 29, 2017 issue of the Texas Register.
   
• Amendment temporarily adding acryl fentanyl to schedule I
  Effective September 29, 2017
  The amendment was published in the September 8, 2017 issue of the Texas Register.

• Amendment temporarily adding 4-fluoroisobutyryl fentanyl to Schedule I
  Effective July 14, 2017
  The amendment was published in the June 23, 2017 issue of the Texas Register.

• Amendment moving 4-MEC, 4-MePPP; alpha-PVP; MBDB, pentylone, flephedrone, 3-FMC, naphyrone, and alpha-PBP, from temporary to final schedule I status
  Effective June 16, 2017
  The amendment was published in the May 26, 2017 issue of the Texas Register.
   
• Amendment temporarily adding 5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA, and MDMB-FUBINACA to schedule 1
  Effective June 16, 2017
  The amendment was published in the May 26, 2017 issue of the Texas Register.
   
• Amendment placing oral solutions containing dronabinol into schedule II
  Effective June 16, 2017
  The amendment was published in the May 26, 2017 issue of the Texas Register.
   
• Final order maintaining brivaracetam in schedule V
  Effective June 16, 2017
  The order was published in the May 26, 2017 issue of the Texas Register.
   
• Amendment creating a separate listing for marijuana extract in schedule I
  Effective June 9, 2017
  The amendment was published in the May 19, 2017 issue of the Texas Register.
   
• Amendment changing the temporary Schedule I status of 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe to final Schedule I status
  Effective April 7, 2017
  The amendment was published in the March 17, 2017 issue of the Texas Register.
   
• Amendment temporarily adding furanyl fentanyl to Schedule I 
  Effective April 7, 2017
  The amendment was published in the March 17, 2017 issue of the Texas Register.
   
• Amendment temporarily adding U-47700 to Schedule I
  Effective January 13, 2017
  The amendment was published in the December 23, 2016 issue of the Texas Register.
   
• Amendment adding PB-22, 5-fluoro-PB-22, AB-FUBINACA and ADB-PINACA to Schedule I
  Effective November 11, 2016
  The amendment was published in the October 21, 2016 issue of the Texas Register.

• Amendment adding thiafentanil to Schedule II
  Effective November 11, 2016
  The amendment was published in the October 21, 2016 issue of the Texas Register.
   
• Amendment adding AH-7921 to Schedule I
  Effective September 30, 2016
  The amendment was published in the September 9, 2016 issue of the Texas Register.
   
• Amendment adding UR-144,  XLR11 and APINACA to Schedule I
  Effective September 30, 2016
  The amendment was published in the September 9, 2016 issue of the Texas Register.
   
• Amendment Temporarily adding butyryl fentanyl and beta-hydroxythiofentanyl to Schedule I
  Effective September 30, 2016
  The amendment was published in the September 9, 2016 issue of the Texas Register.
   
• Amendment adding brivaracetam to Schedule V
  Effective September 30, 2016
  The amendment was published in the September 9, 2016 issue of the Texas Register.

2016 Schedules of Controlled Substances

2016 Schedules of Controlled Substances
​​​​
Effective June 24, 2016
The annual republication was published in the June 3, 2016 issue of the Texas Register (41 TexReg 4086).

• Amendment Temporarily Adding MAB-CHMINACA into Schedule I
  Effective April 22, 2016
  This amendment was published in the April 1, 2016 issue of the Texas Register.
   
• Amendment Adding Eluxadoline into Schedule IV 
  Effective April 22, 2016
  This amendment was published in the April 1, 2016 issue of the Texas Register.

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Schedules of Controlled Substances Archives

Archives of prior schedules and changes can be found on the controlled substance archive page.