STI Treatment Guidelines

CDC released Sexually Transmitted Infections Treatment Guidelines, 2021. This document provides current evidence-based diagnostic, management, and treatment recommendations, and serves as a source of clinical guidance for managing sexually transmitted infections (STIs).

The new guidelines include notable updates from the previous 2015 guidance, including:

  • Updated treatment recommendations for chlamydia, trichomoniasis, and pelvic inflammatory disease.
  • Updated treatment recommendations for uncomplicated gonorrhea in neonates, children, and other specific clinical situations (e.g., proctitis, epididymitis, sexual assault), which builds on broader treatment changes published in Morbidity and Mortality Weekly Report.
  • Information on FDA-cleared diagnostic tests for Mycoplasma genitalium and rectal and pharyngeal chlamydia and gonorrhea.
  • Expanded risk factors for syphilis testing among pregnant patients.
  • Recommended two-step serologic testing for diagnosing genital herpes simplex virus.
  • Harmonized recommendations for human papillomavirus vaccination with the Advisory Committee on Immunization Practices.
  • Recommended universal hepatitis C testing in alignment with CDC’s 2020 hepatitis C testing recommendations.

You can stay informed on the latest STI recommendations and clinical guidance with CDC and partner resources which include:

  • High-quality printable copies of the wall chart, pocket guide, and MMWR, which are available for download now on the CDC STD website. A limited number of free copies will be available for order through CDC-INFO On Demand in the coming weeks.
  • Training and technical assistance, which are available through the National Network of STD Clinical Prevention Training Centers.
  • STD clinical consultation services, which are available through the STD Clinical Consultation Network.
  • Free continuing education credits (CME and CNE), which are available through the National STD Curriculum.
  • Recommendations for Providing Quality STD Clinical Services (or STD QCS), which complement the STI treatment guidelines, focusing on managing clinical operations.
  • An updated STI Treatment Guidelines mobile app, which is in development and is expected to launch in the coming months. NOTE: The 2015 STD Treatment Guidelines app was retired at the end of July 2021. CDC is finalizing an interim, mobile-friendly solution – please visit STI Treatment Guidelines ( for information, as it becomes available.

Thank you for your commitment to improving the sexual health and wellness of people in Texas.