340B Drug Discount Program

About the Program

The 340B Drug Pricing Program is a federal program requiring drug manufacturers that participate in the Medicaid drug rebate program to provide covered outpatient drugs to enrolled covered entities at or below the statutorily defined ceiling price. Section 340B of the Public Health Service Act 42 USC §256b defines and codifies this requirement. The 340B Program allows covered entities “to stretch scarce Federal resources as far as possible, reaching more eligible patients and providing more comprehensive services.” H.R. Rep. No. 102-384(II), at 12 (1992).

The DSHS Central Pharmacy participates in the 340B program to purchase medication for DSHS regional clinics and partner entities serving as the public health entities for Texans


PIOS Training Sessions

Providers need to register their location into PIOS. Providers must complete the required PIOS training prior to registering their location. 

Session Date/Time                 Registration Link
Wed Aug 6, 2025 1:00pm CDThttps://attendee.gotowebinar.com/register/180336845704727640

After registering, you will receive a confirmation email containing information about joining the webinar.


Facility Registration

After completing your PIOS training you are eligible to register your facility by visiting: https://txhhs-covid.my.site.com/PIOSEnrollment/.

**All users listed on the registration form must register and complete a training before DSHS can approve the facility and all its users**

If you need DSHS to add as a new user to an existing facility, you must send an email to 340B@dshs.texas.gov with:

  • User full name
  • Direct email address
  • Direct phone number
  • Facility where they need access 

ALERT: Submitting a registration request for your facility and users does not automatically guarantee access to the Pharmacy Inventory and Ordering System (PIOS). The facility must already be an approved TIPP partner or HIV Prevention contractor with an active 340B STD covered entity registered with an applicable DSHS NOFO or /grant number in HRSA OPAIS. If you complete the PIOS registration without these requirements in place, DSHS will deny your request. 


DSHS 340B Policies and Procedures


340B Resources